هیدروژل فیزیکی کیتوسان جهت درمان زخم دیابتی

Introduction: Diabetes is one of the most common chronic diseases. Diabetes mellitus is a metabolic disorder in the metabolism of fats, carbohydrates and proteins in the body which were caused by the changes in insulin secretion in the body. Diabetes is malfunctioning in the body’s vessels. This research aimed to develop a wound dressing that causes the damaged vessels to be reconstructed and it can improve diabetic wounds as soon as possible. Methods and Materials: In the present study, Chitosan was selected as a biocompatible and biodegradable polymer to form a wound dressing. Moreover, different cross linkers including betaglycerphosphate (BGP), triple polyphosphate (TPP) and alginate (ALg) were added as a Chtoson compositematerial material. Results: Wound dressing has been made from Chitosan with beta-glycerophosphate, tripolyphate and alginate. In the scanning electron microscopy test,the CS-AL sample had the best structure for the number of cavities and uniformity of cavities. In the water absorption test, CS-AL sample had the best water absorption among other samples (3854%).In the wound dressing airborne test, only CS-AL wound dressing was achieved the minimum air  permeation value. In the test of degradibility, the CS-AL sample was 80% degraded after 14 days, which is the appropriate percentage for ulcers. In addition, the GSNO was loaded into this wound dressing. Based on the results of this graval test, we see a peak generated at 540 nm including the release of nitric oxide gas from GSNO powder and GSNO containing ulcer. Discussion and Conclusion: After performing scanning electron microscopy, air permeation testing, water absorption and degradability, the CS-ALg specimen has the best conditions for producing the final wound dressing, then the GSNO powder was added as a release agent for nitric oxide to the wound dressing and the release of gas Nitric oxide was evaluated from the wound dressing. The constructed wound dressing, releases the Nitric oxide gas successfully in regarding to our study results.